ISU Meridian Health Science Center

ISU-Meridian’s Kirk Hevener receives New Investigator Award

Jan. 24, 2014

The American Association of Colleges of Pharmacy has chosen Idaho State University assistant professor Kirk Hevener for a New Investigator Award, one of 12 researchers in the country to receive the honor.

The award, which supports new pharmacy faculty member’s research programs, includes a $10,000 pilot grant and travel expenses to present his research at the annual AACP meeting in July 2015.

Pilot grants are traditionally awarded to junior faculty and allow the opportunity to “take good ideas and turn them into good research projects,” said Hevener. The award will makeKirk Hevener Hevener’s research competitive for larger grants once his project is off the ground.

“I’m very happy to get it,” said Hevener. “It’s my first award since coming to ISU. I’m glad they (the AACP) had confidence in my research to fund it.”

Hevener, who joined the Biological and Pharmaceutical Sciences Department in March 2013, is the newest faculty member at the L.S. Skaggs Pharmacy Complex at the ISU-Meridian Health Science Center.

“Dr. Hevener is part of a small group of energetic new faculty members engaged in structural biology and drug discovery research,” said Dana Diedrich, department chair. “He is a valuable addition to the College and plays a pivotal role in taking the College's research in a new direction.”

Hevener uses protein crystallography in the laboratory to solve the structures of his targets and then uses computer-aided modeling to identify new compounds that can inhibit these targets as drug candidates. His research has focused on infectious diseases of the oral cavity such as periodontal disease as well as infectious diseases of the lower bowel such as Clostridium difficile colitis.

His project will concentrate on characterizing a novel antibacterial target in the C. difficile bacteria and testing to identify inhibitors. Hevener hopes to prove that inhibition of this target, an enzyme called FabK, will result in a selective antibacterial affect against C. difficile.

“Hypervirulent, drug-resistant C. difficile infections result in an estimated 14,000 deaths per year and a national burden in excess of $3 billion annually,” Hevener stated in his abstract. “Broad-spectrum antibiotics can kill off the ‘good’ bacteria in the gut, allowing C. difficile to grow.  Selective antibiotics, such as those we hope to develop, could be used to treat C. difficile infection, while allowing the return of the ‘good’ bacteria.”
One reviewer for the grant called Hevener's work a “highly interesting project that focuses on an unmet need for inhibitors against C. difficile.”

Before joining ISU, Hevener conducted  postdoctoral work at the University of Illinois at Chicago. He received both a Pharm.D. and Ph.D. from the University of Tennessee.

“Dr. Hevener is a wonderful addition to our faculty and has everything it takes to be a successful researcher,” said Paul Cady, College of Pharmacy dean.



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